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KMID : 0931320140140010031
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대한상부위장관.헬리코박터학회지
2014 Volume.14 No. 1 p.31 ~ p.38
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Clinical Characteristics of Peptic Ulcer Disease in Korea
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Lee Min-Young
Kim Joon-Sung
Kim Byung-Wook
Kim Tae-Ho
Chung Woo-Chul
Kim Jin-Il
Park Jae-Myung
Jeon Eun-Jung
Kim Sung-Soo
Lee Dong-Soo
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Abstract
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Background/Aims: Clinical presentation and patterns of peptic ulcer disease (PUD) have changed because surival of people in Korea have increased. Other factors such as declining Helicobacter pylori infection rate and increased consumption of non-steroidal anti-inflammatory drugs (NSAID) including aspirin also affect the clinical patterns of PUD. The aim of this study was to evaluate the current clinical characteristics of PUD in Korea.
Materials and Methods: This study was performed from March 2011 to September 2012 in 8 institutions affiliated to the Catholic University of Korea. When the patients were diagnosed with PUD during endoscopic examination, questionnaires including life style of the patients and the endoscopic findings were obtained. The questionnaires were composed of region of residency, occupational history, blood type, clinical symptoms and signs at the presentation, alcohol history, smoking history, and consumption of drugs such as NSAID. We also analyzed the endoscopic findings of PUD including the numbers, locations, stages, and complications.
Results: A total 815 patients were recruited in this study. The mean age was 56.3±14.5 years old and 496 patients (60.9%) were men. The proportion of gastric ulcer, duodenal ulcer, and combined gastric and duodenal ulcer was 57.3%, 32.1%, and 10.6%, respectively. H. pylori infection was detected in 548 patients (67.2%) and drug-related PUD was found in 278 patients (34.1%). Complication such as bleeding, obstruction, and perforation was found in 174 patients (21.3%).
Conclusions: H. pylori-related PUD is still high in Korea. Among patients with PUD, elderly patients consume much more drugs such as NSAIDs compared to younger patients.
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KEYWORD
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Peptic ulcer, Helicobacter pylori, Anti-inflammatory agents, non-steroidal
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